Long‐term course of bronchial inflammation and pulmonary function testing in children with postinfectious bronchiolitis obliterans

Rationale Postinfectious bronchiolitis obliterans (PIBO) is a rare, chronic respiratory condition, which follows an acute insult due to severe infection of the lower airways. Objectives The objective this study was investigate long-term course bronchial inflammation and pulmonary function testing in children with PIBO. Methods Medical charts 21 PIBO were analyzed retrospectively at Children's University Hospital Frankfurt/Main Germany. Pulmonary tests (PFTs) interval least 1 month studied between 2002 2019. A total 382 PFTs per year, two best PFTs, 217, evaluated. Additionally, 56 sputum analysis assessed neutrophils Results evaluation 217 showed decrease FEV1 loss 1.07% z score −0.075 year. FEV1/FVC decreased by 1.44 FVC remained stable, showing nonsignificant increase 0.006 However, L increased significantly 0.032 cm 0.048 L/cm height. Sputum significant 2.12% Conclusion Our results demonstrated that patients persistent obstruction over average follow-up period 8 years. lung growth revealed. In addition, persisted clearly increasing amount induced sputum. Patients did not present general susceptibility infections.